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Rays prospect Xavier Isaac returns to action in first game since undergoing brain surgery

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Last updated: March 1, 2026 3:06 am
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Published: March 1, 2026
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Despite their 12-3 loss to the Tigers, the Rays and their prospect Xavier Isaac had a heartfelt moment on Saturday.

In his first game back from having brain surgery last year, Isaac, 22, singled to right field in the eighth inning, a moment which was celebrated by his Rays teammates.

“It was awesome. The dugout was pumped up. Everybody shook his hand, high-fived him,” Rays manager Kevin Cash told reporters, according to MLB.com. “No, [his results] don’t matter.


Xavier Isaac, wearing a blue helmet and jersey, high-fives another baseball player.
Xavier Isaac accepts congratulations from his first base coach after singling to right field in the eighth inning of the Rays’ 12-3 spring training loss to the Tigers on Feb. 26, 2026. Tampa Bay Rays/X

“But any time you get some positive reinforcement or a reward for the work that he’s been putting in on the back field — hopefully he values that as a pretty special moment. I know we all did.”

Isaac, who was selected by Tampa Bay with the No. 29-overall pick in the 2022 MLB Draft, underwent “life-saving” surgery back in July 2025 to remove a brain tumor, which sidelined the first baseman for more than eight months.

“Just being back on the field, just being at first, honestly, was the best. I haven’t been on defense in two years, so that was a good moment,” Isaac said. “And I got the hit. A lot of relief.”

Isaac last played for Double-A Montgomery before his surgery, which he previously said was “the scariest moment” of his life.


Xavier Isaac of the Tampa Bay Rays reacts as he returns to the dugout after hitting a two-run home run.
Xavier Isaac celebrates after hitting a two-run homer in the top of the Rays’ spring training loss to the Twins on March 16, 2024 in Fort Myers, Fla. Getty Images

“As soon as I found out that, I was definitely not worried about baseball,” Isaac told reporters earlier this month.

Isaac is now spending spring training with the Rays as a non-roster invitee as he prepares for his fifth professional season.

After impressing across both Low-and High-A during the 2023-24 seasons, Isaac’s stats dipped last season, which he admitted was likely linked to his brain tumor.

“Mentally, I feel like I wasn’t there last year, wasn’t the same there, and it was something wrong — and I did not know what was going on,” Isaac said. “It was probably that, and that’s a big reason why.”

Isaac was the Rays’ ninth-ranked prospect in 2025, according to MLB.com

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