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Giants vs. Commanders prediction: NFL Week 5 picks, odds, best bets for Sunday

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Last updated: October 11, 2026 1:12 pm
amedpost
Published: October 11, 2026
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Contents
  • Giants vs. Commanders prediction
  • Betting on the NFL?
  • Why Trust New York Post Betting
Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

The Giants are a prime example of the oddities of an NFL season.

They comfortably leading the NFC East entering Week 5 despite losing starting quarterback Jaxson Dart to a season-ending injury in Week 2. They scored 18 points combined over a two-week stretch then exploded for 36 points in Week 4.

Fans of Big Blue will happily take the results, but anyone who says they know what to expect from the Giants week-to-week, including the G-Men themselves, should take a lie detector test.

They head to Maryland to face the Commanders this week, who are 3.5-point home favorites with quarterback Jayden Daniels back under center after an elbow injury.

Giants vs. Commanders prediction

The Jameis Winston experience was on full display last week.

He made some risky throws that turned into big plays for the Giants, including touchdowns to Malik Nabers, Malachi Fields and Theo Johnson.

He also had some confounding interceptions — one on an overthrow to Isaiah Likely and another that was a gift to the Cardinals defense.


New York Giants quarterback Jameis Winston throws the ball as he is hit by Arizona Cardinals linebacker Josh Sweat.
New York Giants quarterback Jameis Winston (19) throws as he is hit by Arizona Cardinals linebacker Josh Sweat, left, during an NFL football game in East Rutherford, N.J., Sunday, Oct. 4, 2026. AP Photo/Seth Wenig

The risk-reward proposition comes with the territory when Winston is your quarterback, but the Giants have to roll with it as he’s their best option at quarterback.

The Commanders will have their starting QB back but won’t have Stefon Diggs, who is out with a hamstring injury. Terry McLaurin, who is also dealing with hamstring, will be a game-time decision. If Daniels is close to fully healthy, he should still be effective for Washington, but losing both top targets will be a blow.


Betting on the NFL?


The real concern for Washington should be its defense, which has allowed 30 points in three consecutive games. Their pass defense has allowed 11 touchdowns through the air this season, which is tied for the most in the NFL.

Winston should be able to move the ball against the Commanders. His turnovers may give the Commanders extra opportunities to score on offense, but he can still take advantage of a susceptible defense and keep Big Blue in this game late.

I’ll take the points with the Giants on the road.

The Pick: Giants +3.5 (-110, DraftKings Sportsbook)


Why Trust New York Post Betting

Malik Smith has been immersed in the sports betting industry since 2017. He’s a data nerd with a particular focus on the NBA and combat sports. He spends his weeknights in the winter looking for edges on plus-money NBA player props.

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