The Mariners and Astros will play the second game of a four-game set on Saturday after a 9-6 Seattle win to open the series.
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Lance McCullers Jr. (1-0, 3.27 ERA) will start for Houston against Seattle’s Luis Castillo (0-0, 2.79 ERA).
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What our Post expert thinks about Astros vs. Mariners
McCullers Jr. will make his third start of the season after allowing four runs on nine hits with 13 strikeouts over 11 innings. In his most recent outing Sunday, he took a no-decision in a 12-10, 10-inning loss to the Athletics, giving up three earned runs over four innings in his first road start of 2026.
Castillo, also making his third start of the season, has permitted three earned runs on nine hits and three walks with 11 strikeouts across 9 2/3 innings. He last pitched Sunday, taking a no-decision in an 8-7, 11-inning road loss to the Angels after allowing four runs (three earned) over 3 2/3 innings.
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Why Trust New York Post Betting
Sean Treppedi handicaps the NFL, NHL, MLB and college football for the New York Post. He primarily focuses on picks that reflect market value while tracking trends to mitigate risk.