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Florida State vs. Louisville prediction: Odds, picks, best bet for Friday’s ACC clash

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Last updated: October 9, 2026 7:02 pm
amedpost
Published: October 9, 2026
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Contents
  • Louisville vs. Florida State odds, pick
    • Get the lowdown on the Best USA Sports Betting Sites and Apps
  • Why Trust New York Post Betting
Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

Don’t look now, but Florida State has won two games in a row and can announce itself as an ACC contender with a win over Louisville on Friday night.

The latter part of that sentence may be a stretch, but don’t tell that to the Seminoles after they drubbed Virginia, 38-7, in Week 5.

Perhaps Mike Norvell will keep his job after all? Well, let’s not get carried away.

The Seminoles are 3.5-point underdogs in Louisville on Friday, and they’ve got Miami on deck.

Things could go pear-shaped, again, pretty quickly.

Louisville vs. Florida State odds, pick

It’s really hard to trust either of these Jekyll-and-Hyde teams.

Louisville started the campaign on the right foot, giving Ole Miss a run for its money, crushing Villanova, and then defeating SMU, but it’s gone off the rails since then for the Cardinals. They’ve lost two in a row to Wake Forest and NC State, and will see their season go up in smoke with a loss on Saturday.

Florida State has followed the opposite pattern. The Seminoles won ugly in Week 0 against New Mexico State, lost to SMU in a game that was a lot uglier than the scoreboard suggested, and then got blitzed for 50 points against Alabama. The Seminoles got right against Central Arkansas in Week 4, but nobody was expecting the performance that came against Virginia.


Get the lowdown on the Best USA Sports Betting Sites and Apps


Quarterback Ashton Daniels has struggled this season, but he completely took over against the Cavaliers, setting a record with five rushing touchdowns.

The much-maligned defense also turned into a force against the Cavs, which was completely unexpected.

But here’s the thing: Virginia just isn’t that good.

Louisville may be scratching their heads after the last two weeks, but the Cardinals should have more than enough offensive firepower to expose a defense that has had one impressive performance this season.


Florida State Seminoles head coach Mike Norvell stands on the field with his hands on his hips before a game.
Florida State Seminoles head coach Mike Norvell. IMAGN IMAGES via Reuters Connect

Quarterback Lincoln Kienholz, who was upgraded to probable for this clash, has been more than capable under center for Louisville this season, but he’s also got the luxury of a rushing attack that is averaging 5.3 yards per attempt.

If this game were played last weekend, this number would have felt like a gift. Buy low on Louisville and sell high on Florida State.

The Play: Louisville -3.5 (-110, DraftKings)


Why Trust New York Post Betting

Michael Leboff is a long-suffering Islanders fan, but a long-profiting sports bettor with 10 years of experience in the gambling industry. He loves using game theory to help punters win bracket pools, find long shots, and learn how to beat the market in mainstream and niche sports.

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