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Brewers vs. Padres prediction, Game 3 pick: Odds, best bets for NLDS Tuesday

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Last updated: October 6, 2026 9:51 pm
amedpost
Published: October 6, 2026
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Contents
  • Brewers vs. Padres NLDS prediction, props
    • Learn all you need to know about MLB Betting
  • Why Trust New York Post Betting
Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

Losing by one run in any MLB postseason game stings, but losing two back-to-back stings even more.

In both Games 1 and 2 of the NLDS, San Diego jumped out to early 2-0 leads against Milwaukee, only to blow each one in devastating fashion. 

The Padres could easily be up 2-0 in the series and on the verge of closing out the NLDS at home. 

Instead, they return to Petco Park with their season on the brink.

Jackson Chourio’s playoff legend keeps growing by the minute, and the Brewers are now one win away from reaching the NLCS.

The Brewers enter Game 3 as underdogs, with the Padres listed as -130 moneyline favorites on Fanatics Sportsbook. 

Brewers vs. Padres NLDS prediction, props

After burning through their top two arms in Jacob Misiorowski and Logan Henderson, the Brewers send Dustin May to the mound for Game 3. 

Pitching on the road has been a struggle this season for the former Dodger and Cardinal, who was acquired at the trade deadline by Milwaukee.

As a road pitcher this season, May has a 2-4 record and a 5.88 ERA, allowing 64 hits and 10 home runs while striking out 59 over 56 ⅔ innings. 


Milwaukee Brewers' Dustin May pitches during a baseball game against the Philadelphia Phillies.
Dustin May is listed as the Brewers’ starting pitcher in Game 3. AP Photo/Matt Rourke

During his last trip to San Diego in August, May surrendered four hits, struck out six, and finished with a 1.29 ERA over seven innings.

This is a silver lining for the Padres.

The intensity of the playoffs brings a different level of play, and with San Diego harping on two close losses, I expect several hitters to be locked in, starting with Manny Machado.


Learn all you need to know about MLB Betting


After a brutal 0-for-2 showing in Sunday’s loss, the third baseman is due for redemption. 

Through four playoff games, Machado leads the Padres with ten total bases and is one of four hitters to go yard for San Diego. 

Look for the veteran third baseman to deliver at the plate against May, who he has faced 42 times in his career, collecting 10 hits, 2 homers, and 5 RBIs for a .238 average.

THE PLAY: SGP (+140, Fanatics Sportsbook): Padres moneyline (-140) + Manny Machado over 0.5 total bases (-185)


Why Trust New York Post Betting

Mike Turay is a sports journalist and editor who closely follows the NBA, NFL, college sports and UFC. He has demonstrated expertise in both NBA and NFL player prop bets for nearly three years. Mike is also highly knowledgeable about the sportsbook offer landscape, frequently trying and reviewing the latest apps and sites.

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