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49ers overtake Rams as Super Bowl favorites in major odds shakeup

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Last updated: October 14, 2026 9:46 pm
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Published: October 14, 2026
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For the first time this season, the Rams are no longer the favorites to win the Super Bowl.

Instead, another NFC West team has taken the lead in betting odds.

The 49ers are now favorited to win the division, the NFC and the Super Bowl, according to DraftKings Sportsbook.


San Francisco 49ers quarterback Brock Purdy raises his fist while acknowledging fans after defeating the Seattle Seahawks.
San Francisco 49ers quarterback Brock Purdy (13) acknowledges 49ers fans in the crowd after defeating the Seattle Seahawks at Lumen Field. IMAGN IMAGES via Reuters Connect

The 49ers are favored to win the Super Bowl, the NFC and the NFC West 🔥

It’s the first time this season the Rams are not the Super Bowl favorites 🤯 pic.twitter.com/6FgmGSimoo

— ESPN BET (@ESPNBET) October 14, 2026

As the NFL enters Week 6, the 49ers are one of three undefeated teams remaining.

San Francisco stunned the football world with its season opening performance against the Rams, who were slated to be a juggernaut with the return of Aaron Donald and acquisition of Myles Garrett.

Instead, the 49ers handed Los Angeles an absolute beatdown in Week 1.


San Francisco 49ers running back Christian McCaffrey (23) celebrates with wide receiver Deebo Samuel Sr. (19).
San Francisco 49ers running back Christian McCaffrey (23) celebrates with wide receiver Deebo Samuel Sr. (19) after running for an eleven-yard touchdown against the Seattle Seahawks during the first half at Lumen Field. IMAGN IMAGES via Reuters Connect

Since then, the 49ers have proved to be a legitimate Super Bowl contender with huge wins over the Broncos and Seahawks.

As for the Rams, the super team hasn’t quite lived up to expectations sitting at third place in the division. LA is coming off a tough overtime loss to the Bills, a true AFC contender.


Betting on the NFL?


The Rams, with a 2-3 record, have endured several close games this season with a memorable win over Philadelphia but a crushing defeat to Denver.

The margin for error in the NFC West has been extremely thin in recent seasons, especially in 2026.

But it appears the 49ers are separating themselves from the pack.



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